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Article

MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.

Molecular cancer - 14 Sept 2021

Li Haichang, Lin Pei-Hui, Gupta Pranav, Li Xiangguang, Zhao Serena Li, Zhou Xinyu, Li Zhongguang, Wei Shengcai, Xu Li, Han Renzhi, Lu Jing, Tan Tao, Yang Dong-Hua, Chen Zhe-Sheng, Pawlik Timothy M, Merritt Robert E, Ma Jianjie

Abstract excerpt

BACKGROUND: Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2. Selective control of G3BP2/SG signaling is a potential means to treat non-small cell lung cancer (NSCLC). METHODS: Co-immunoprecipitation was conducted to identify the interaction of MG53 and G3BP2. Immunohistochemistry and live cell...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 34521423
DOI: 10.1186/s12943-021-01418-3
PMCID: PMC8439062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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