Article
Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer.
Oncology reports - 1 Feb 2020
Tang Xinyu, Li Yang, Liu Long, Guo Rui, Zhang Ping, Zhang Yihe, Zhang Yong, Zhao Jia, Su Jing, Sun Liankun, Liu Yanan
Abstract excerpt
Mutation of the p53 tumor suppressor frequently occurs in lung cancer, and can be as high as 75‑90% in small‑cell lung cancer. Mutant p53 (mtp53) can inhibit the wild‑type p53 protein, disrupting its tumor suppressor functions. In addition, mutant p53 often acquires the functions of an oncogene. Post‑translational modification of the p53 protein is important for its transcriptional and tumor suppressive...
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