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Article

Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3.

Journal of cancer research and clinical oncology - 20 Jun 2024

Feng Yu, Qian Rulin, Cui Dong, Luan Jiaqiang, Xu Mingxing, Wang Ling, Li Ruijie, Wu Xiao, Chang Chaoying

Abstract excerpt

PURPOSE: Targeted therapies have markedly improved the prognosis of lung cancer patients; nevertheless, challenges persist, including limited beneficiary populations and the emergence of drug resistance. This study investigates the molecular mechanisms of mutant TP53 in lung cancer, aiming to contribute to novel strategies for targeted therapy. METHODS: The TCGA database was employed to delineate the mutational...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 38900156
DOI: 10.1007/s00432-024-05778-3
PMCID: PMC11189974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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