Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation.

Redox biology - 1 Apr 2025

Wang Liansheng, Zhong Suqin, Fan Xinru, Xu Yuxue, Wang Meimei, Xu Youcui, Cai Yuanyuan, Cao Zhong, Ye Zhiming, Wen Longping, Wei Pengfei

Abstract excerpt

Mutp53 level is widely variable among individual cancer cells in tumor tissues, and within cells a higher level of mutp53 is usually observed in the nucleus as compared to the cytoplasm. This spatial heterogeneity in mutp53 expression has been well documented and likely plays an important role in tumor therapeutic resistance. However, its underlying mechanism remains poorly understood. In this study, we first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione

Share to Glutathione Reductase

Share to Neoplasms

Share to Protein Stability

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 39983342
DOI: 10.1016/j.redox.2025.103522
PMCID: PMC11893312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation.PMID 39983342Read ↗

RSL3 sensitizes glioma cells to ionizing radiation by suppressing TGM2-dependent DNA damage repair and epithelial-mesenchymal transitionSemantic proximity Read ↗

Gambogic acid restores wild-type-like p53 functions to induce ferroptosis in mutant p53 cancer cells.Semantic proximity Read ↗

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation.Semantic proximity Read ↗

Curcumin mediates selective aggregation of mutant p53 in cancer cells: A promising therapeutic strategy.Semantic proximity Read ↗

Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization EffectSemantic proximity Read ↗

Metabolic regulation by p53 prevents R-loop-associated genomic instabilitySemantic proximity Read ↗

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCCSemantic proximity Read ↗

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.Semantic proximity Read ↗

Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication.Semantic proximity Read ↗

3‐Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinomaSemantic proximity Read ↗

Identification of mutant p53-specific proteins interaction network using TurboID-based proximity labeling.Semantic proximity Read ↗

Glutathionylation-dependent proteasomal degradation of wide-spectrum mutant p53 proteins by engineered zeolitic imidazolate framework-8.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.