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Article

Mutant p53 achieves function by regulating EGR1 to induce epithelial mesenchymal transition.

Tissue & cell - 1 Oct 2024

Meng Weipei, Yu Shilong, Li Yan, Wang Haichen, Feng Yuqing, Sun Wanyue, Liu Ying, Sun Shilong, Liu Haifeng

Abstract excerpt

The epithelial-mesenchymal transition (EMT) plays a crucial role in lung cancer metastasis, rendering it a promising therapeutic target. Research has shown that non-small cell lung cancer (NSCLC) with p53 mutations exhibits an increased tendency for cancer metastasis. However, the exact contribution of the p53-R273H mutation to tumor metastasis remains uncertain in the current literature. Our study established...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 39126833
DOI: 10.1016/j.tice.2024.102510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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