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Article

The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.

The Journal of clinical investigation - 15 Mar 2023

Liu Juan, Zhang Cen, Xu Dandan, Zhang Tianliang, Chang Chun-Yuan, Wang Jianming, Liu Jie, Zhang Lanjing, Haffty Bruce G, Zong Wei-Xing, Hu Wenwei, Feng Zhaohui

Abstract excerpt

The tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote cancer progression through the gain-of-function (GOF) mechanism. Currently, the mechanism underlying mutp53 accumulation and GOF is incompletely understood. Here, we identified TRIM21 as a critical E3 ubiquitin ligase of mutp53 by screening...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36749630
DOI: 10.1172/JCI164354
PMCID: PMC10014102

Genes

TRIM21
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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