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Article

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Croessmann Sarah, Wong Hong Yuen, Zabransky Daniel J, Chu David, Mendonca Janet, Sharma Anup, Mohseni Morassa, Rosen D Marc, Scharpf Robert B, Cidado Justin, Cochran Rory L, Parsons Heather A, Dalton W Brian, Erlanger Bracha, Button Berry, Cravero Karen, Kyker-Snowman Kelly, Beaver Julia A, Kachhap Sushant, Hurley Paula J, Lauring Josh, Park Ben Ho

Abstract excerpt

The tumor protein 53 (TP53) tumor suppressor gene is the most frequently somatically altered gene in human cancers. Here we show expression of N-Myc down-regulated gene 1 (NDRG1) is induced by p53 during physiologic low proliferative states, and mediates centrosome homeostasis, thus maintaining g...

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Identifiers

PMID: 26324937
DOI: 10.1073/pnas.1503683112
PMCID: PMC4577188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26324937-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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