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Article

Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15

18 Jun 2012

Abstract excerpt

Identification of the cellular mechanisms that mediate cancer cell chemosensitivity is important for developing new cancer treatment strategies. Several chemotherapeutic drugs increase levels of the posttranslational modifier ISG15, which suggests that ISGylation could suppress oncogenesis. However, how ISGylation of specific target proteins controls tumorigenesis is unknown. Here, we identified proteins that are...

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PMID: 22706304
DOI: 10.1172/jci61762

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