Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MG53-mediated cell membrane repair protects against acute kidney injury.

Science translational medicine - 18 Mar 2015

Duann Pu, Li Haichang, Lin Peihui, Tan Tao, Wang Zhen, Chen Ken, Zhou Xinyu, Gumpper Kristyn, Zhu Hua, Ludwig Thomas, Mohler Peter J, Rovin Brad, Abraham William T, Zeng Chunyu, Ma Jianjie

Abstract excerpt

Injury to the renal proximal tubular epithelium (PTE) represents the underlying consequence of acute kidney injury (AKI) after exposure to various stressors, including nephrotoxins and ischemia/reperfusion (I/R). Although the kidney has the ability to repair itself after mild injury, insufficient repair of PTE cells may trigger inflammatory and fibrotic responses, leading to chronic renal failure. We report that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

Share to Kidney

Share to Kidney Tubules

Share to Mice, Nude

Share to Rats, Sprague-Dawley

Share to Tripartite Motif Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25787762
DOI: 10.1126/scitranslmed.3010755
PMCID: PMC4524523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MG53-mediated cell membrane repair protects against acute kidney injury.PMID 25787762Read ↗

Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes.Semantic proximity Read ↗

Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.Semantic proximity Read ↗

ERMP1 as a newly identified endoplasmic reticulum stress gatekeeper in chronic kidney diseaseSemantic proximity Read ↗

Gremlin1 plays a key role in kidney development and renal fibrosis.Semantic proximity Read ↗

FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injurySemantic proximity Read ↗

Vitamin B12 Protects the Exacerbated Ischemia-Reperfusion Injury Induced Chronic-Kidney-Disease in Mice with Genetically Increased Elmo1Semantic proximity Read ↗

p53 is renoprotective after ischemic kidney injury by reducing inflammation.Semantic proximity Read ↗

ELMO1 dependent efferocytosis protects from nephrotoxin induced acute kidney injurySemantic proximity Read ↗

Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2BSemantic proximity Read ↗

MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.Semantic proximity Read ↗

Genetic kidney disease: Uromodulin in ER stress and apoptosis.Semantic proximity Read ↗

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient HamstersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.