Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging roles of CST in maintaining genome stability and human disease.

Frontiers in bioscience (Landmark edition) - 1 Mar 2018

Stewart Jason A, Wang Yilin, Ackerson Stephanie M, Schuck Percy Logan

Abstract excerpt

The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding protein that shares homology with RPA and interacts with DNA polymerase alpha/primase. CST complexes are conserved from yeasts to humans and function in telomere maintenance. A common role of CST across species is in the regulation of telomere extension by telomerase and C-strand fill-in synthesis. However, recent studies also indicate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease
Share to DNA Repair Mechanisms
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Mutation

Share to Neoplasms

Share to Telomere-Binding Proteins

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 29293451
DOI: 10.2741/4661
PMCID: PMC6309963

Genes

CTC1
STN1
TEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging roles of CST in maintaining genome stability and human disease.PMID 29293451Read ↗

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-InSemantic proximity Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

Mammalian CST averts replication failure by preventing G-quadruplex accumulationSemantic proximity Read ↗

Pol α-primase dependent nuclear localization of the mammalian CST complex.Semantic proximity Read ↗

Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin associationSemantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

Molecular basis of telomere syndrome caused by CTC1 mutations.Semantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication StressSemantic proximity Read ↗

Structure of the Human Telomeric Stn1-Ten1 Capping ComplexSemantic proximity Read ↗

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.Semantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.