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The DNA methylation landscape of primary triple-negative breast cancer

28 Mar 2025

Abstract excerpt

Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape of TNBC. By analyzing tumor methylome profiles and accounting for the genomic context of CpG methylation, we divide TNBC into two epigenetic subtypes corresponding to a Basal and a non-Basal group, in which characteristic transcriptional patterns...

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PMID: 40155623
DOI: 10.1038/s41467-025-58158-x

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