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Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer

10 Sept 2021

Abstract excerpt

Abstract Conditional overexpression of histone readerTripartitemotif containing protein 24 (TRIM24) in mouse mammary epithelia (Trim24COE) drives spontaneous development of mammary carcinosarcoma tumors, lacking ER, PR and HER2. Human carcinosarcomas or metaplastic breast cancers (MpBC) are a rare, chemorefractory subclass of triple-negative breast cancers (TNBC). Comparison ofTrim24COEmetaplastic carcinosarcoma...

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PMID: 34508101
DOI: 10.1038/s41467-021-25650-z

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