Article

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

2020-06-22

Abstract excerpt

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of the human disease. Here, we generated a unique mouse model ( MMTV-R26 Met mice) of mammary tumors driven by a subtle increase in the expression of the wild-type MET receptor. MMTV-R26 Met mic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d317e85e-d843-55a8-a3d8-959d8acd8ae9
DOI: 10.1101/2020.06.22.164418

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug ResistanceDOI 10.1101/2020.06.22.164418Read

Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug ResistanceSemantic proximity Read

A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast CancerSemantic proximity Read

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulatorsSemantic proximity Read

MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.Semantic proximity Read

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.Semantic proximity Read

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.Semantic proximity Read

Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors.Semantic proximity Read

Murine models for triple-negative breast cancer with differential responsiveness to immunotherapySemantic proximity Read

Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneitySemantic proximity Read

A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.Semantic proximity Read

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer.Semantic proximity Read

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast CancersSemantic proximity Read