TRIM28 in cancer and cancer therapy

Abstract excerpt

TRIM28 (tripartite motif protein 28) was initially believed to be a transcription inhibitor that plays an important role in DNA damage repair (DDR) and in maintaining cancer cellular stemness. As research has continued to deepen, several studies have found that TRIM28 not only has ubiquitin E3 ligase activity to promote degradation of substrates, but also can promote SUMOylation of substrates. Although TRIM28 is...

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• Cancer Mechanisms and Therapy
• interferon and immune responses
• Ubiquitin and proteasome pathways