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Article

Role of the Tripartite Motif Protein 27 in Cancer Development

3 May 2012

Abstract excerpt

BACKGROUND: The tripartite motif family protein 27 (TRIM27) is a transcriptional repressor that interacts with, and attenuates senescence induction by, the retinoblastoma-associated protein (RB1). High expression of TRIM27 was noted in several human cancer types including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis. Here, we investigated the role of TRIM27 expression in...

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PMID: 22556269
DOI: 10.1093/jnci/djs224

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