Article
MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.
Nature communications - 13 Sept 2023
Doha Zinab O, Wang Xiaoyan, Calistri Nicholas L, Eng Jennifer, Daniel Colin J, Ternes Luke, Kim Eun Na, Pelz Carl, Munks Michael, Betts Courtney, Kwon Sunjong, Bucher Elmar, Li Xi, Waugh Trent, Tatarova Zuzana, Blumberg Dylan, Ko Aaron, Kirchberger Nell, Pietenpol Jennifer A, Sanders Melinda E, Langer Ellen M, Dai Mu-Shui, Mills Gordon, Chin Koei, Chang Young Hwan, Coussens Lisa M, Gray Joe W, Heiser Laura M, Sears Rosalie C
Abstract excerpt
Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop a female TNBC murine model by mimicking two common TNBC mutations with high co-occurrence: amplification of the oncogene MYC and deletion of the tumor suppressor PTEN. This...
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