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Article

Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity.

Breast cancer research : BCR - 7 Oct 2023

Broeker Carson D, Ortiz Mylena M O, Murillo Michael S, Andrechek Eran R

Abstract excerpt

BACKGROUND: Breast cancer is a complex and heterogeneous disease with distinct subtypes and molecular profiles corresponding to different clinical outcomes. Mouse models of breast cancer are widely used, but their relevance in capturing the heterogeneity of human disease is unclear. Previous studies have shown the heterogeneity at the gene expression level for the MMTV-Myc model, but have only speculated on the...

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PMID: 37805590
DOI: 10.1186/s13058-023-01723-3
PMCID: PMC10559619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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