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Article

Pan-cancer illumination of TRIM gene family reveals immunology regulation and potential therapeutic implications.

Human genomics - 2 Dec 2022

Gao Yueying, Pan Tao, Xu Gang, Li Si, Guo Jing, Zhang Ya, Xu Qi, Pan Jiwei, Ma Yanlin, Xu Juan, Li Yongsheng

Abstract excerpt

BACKGROUND: The tripartite motif (TRIM) proteins function as important regulators in innate immunity, tumorigenesis, cell differentiation and ontogenetic development. However, we still lack knowledge about the genetic and transcriptome alterations landscape of TRIM proteins across cancer types. METHODS: We comprehensively reviewed and characterized the perturbations of TRIM genes across > 10,000 samples across 33...

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Identifiers

PMID: 36461099
DOI: 10.1186/s40246-022-00441-9
PMCID: PMC9719184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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