Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bubble lifetimes in DNA gene promoters and their mutations affecting transcription.

The Journal of chemical physics - 7 Sept 2021

Hillebrand M, Kalosakas G, Bishop A R, Skokos Ch

Abstract excerpt

Relative lifetimes of inherent double stranded DNA openings with lengths up to ten base pairs are presented for different gene promoters and corresponding mutants that either increase or decrease transcriptional activity in the framework of the Peyrard-Bishop-Dauxois model. Extensive microcanonical simulations are used with energies corresponding to physiological temperature. The bubble lifetime profiles along...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Mutation

Share to Nucleic Acid Conformation

Share to Promoter Regions, Genetic

Share to Transcription, Genetic

Source

Identifiers

PMID: 34496591
DOI: 10.1063/5.0060335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bubble lifetimes in DNA gene promoters and their mutations affecting transcription.PMID 34496591Read ↗

Structural features of DNA that determine RNA polymerase II core promoter.Semantic proximity Read ↗

DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation.Semantic proximity Read ↗

Rationally designed bidirectional promoter improves the evolutionary stability of synthetic genetic circuits.Semantic proximity Read ↗

Next generation sequencing-based parallel analysis of melting kinetics of 4096 variants of a bacterial promoter.Semantic proximity Read ↗

On the spontaneous stochastic dynamics of a single gene: complexity of the molecular interplay at the promoter.Semantic proximity Read ↗

The Transcription Machinery and the Driving Force of the Transcriptional Molecular Condensate: The Role of PhosphatesSemantic proximity Read ↗

DNA sequence, physics, and promoter function: Analysis of high-throughput data On T7 promoter variants activity.Semantic proximity Read ↗

The Transcription Machinery Driving Force: Why Did Nature Choose Phosphates?Semantic proximity Read ↗

Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.Semantic proximity Read ↗

Escherichia coli RNA polymerase contacts outside the -10 promoter element are not essential for promoter melting.Semantic proximity Read ↗

The G+C-rich discriminator region of the tyrT promoter antagonises the formation of stable preinitiation complexes.Semantic proximity Read ↗

Indirect read-out of the promoter DNA by RNA polymerase in the closed complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.