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Article

The G+C-rich discriminator region of the tyrT promoter antagonises the formation of stable preinitiation complexes.

Journal of molecular biology - 16 Jun 2000

Pemberton I K, Muskhelishvili G, Travers A A, Buckle M

Abstract excerpt

RNA polymerase forms a highly stable preinitiation complex at many prokaryotic promoters in the absence of ribonucleotides. These are often characterised by the longevity of the DNA strand-separated (open) complex in the presence of heparin. In contrast, such complexes are notoriously unstable at the promoters for rRNA and tRNA under similar conditions. The high G+C content within the DNA-melting region of these...

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PMID: 10843842
DOI: 10.1006/jmbi.2000.3780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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