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Article

Rationally designed bidirectional promoter improves the evolutionary stability of synthetic genetic circuits.

Nucleic acids research - 7 Jan 2013

Yang Song, Sleight Sean C, Sauro Herbert M

Abstract excerpt

One problem with synthetic genes in genetically engineered organisms is that these foreign DNAs will eventually lose their functions over evolutionary time in absence of selective pressures. This general limitation can restrain the long-term study and industrial application of synthetic genetic circuits. Previous studies have shown that because of their crucial regulatory functions, prokaryotic promoters in...

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Identifiers

PMID: 23093602
DOI: 10.1093/nar/gks972
PMCID: PMC3592475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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