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Article

DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation.

Nucleic acids research - 1 Apr 2010

Alexandrov Boian S, Gelev Vladimir, Yoo Sang Wook, Alexandrov Ludmil B, Fukuyo Yayoi, Bishop Alan R, Rasmussen Kim Ø, Usheva Anny

Abstract excerpt

We assess the role of DNA breathing dynamics as a determinant of promoter strength and transcription start site (TSS) location. We compare DNA Langevin dynamic profiles of representative gene promoters, calculated with the extended non-linear PBD model of DNA with experimental data on transcription factor binding and transcriptional activity. Our results demonstrate that DNA dynamic activity at the TSS can be...

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Identifiers

PMID: 20019064
DOI: 10.1093/nar/gkp1084
PMCID: PMC2847213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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