Article
Indirect read-out of the promoter DNA by RNA polymerase in the closed complex.
Nucleic acids research - 7 Jan 2013
Debnath Subrata, Roy Neeladri Sekhar, Bera Indrani, Ghoshal Nanda, Roy Siddhartha
Abstract excerpt
Transcription is initiated when RNA polymerase recognizes the duplex promoter DNA in the closed complex. Due to its transient nature, the closed complex has not been well characterized. How the initial promoter recognition occurs may offer important clues to regulation of transcription initiation. In this article, we have carried out single-base pair substitution experiments on two Escherichia coli promoters...
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