Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upregulation of inflammatory genes and pathways links obesity to severe COVID-19

26 Jun 2024

Abstract excerpt

Obesity is a risk factor for developing severe COVID-19. However, the mechanism underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a study in which 2-3-month-old K18-hACE2 (K18) mice were fed a western high-fat diet (WD) or normal chow (NC) over 3 months before intranasal infection with a sublethal dose of SARS-CoV2 WA1 (a strain ancestral to the Wuhan variant). After infection,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Cardiovascular Disease and Adiposity
Share to COVID-19 Clinical Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38942338
DOI: 10.1016/j.bbadis.2024.167322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upregulation of inflammatory genes and pathways links obesity to severe COVID-19PMID 38942338Read ↗

Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2Semantic proximity Read ↗

Diet induced obesity and type 2 diabetes drives exacerbated sex-associated disease profiles in K18-hACE2-mice challenged with SARS-CoV-2Semantic proximity Read ↗

Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus InfectionSemantic proximity Read ↗

Obesity fosters severe disease outcomes in a mouse model of coronavirus infection associated with transcriptomic abnormalitiesSemantic proximity Read ↗

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19Semantic proximity Read ↗

Regulation of angiotensin converting enzyme 2 (ACE2) in obesity: implications for COVID-19Semantic proximity Read ↗

Obesity associated with attenuated tissue immune cell responses in COVID-19Semantic proximity Read ↗

Obesity is associated with a distinct innate immune phenotype in severe COVID-19 patientsSemantic proximity Read ↗

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice.Semantic proximity Read ↗

Obesity-Associated Changes in Immune Cell Dynamics During Alphavirus Infection Revealed by Single Cell Transcriptomic AnalysisSemantic proximity Read ↗

Obesity and its impact on COVID-19Semantic proximity Read ↗

Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.