Article

Functional Multi-Omics Reveals Noncanonical Function of G9a in Translational Regulation of Chronic Inflammation

2021-11-12

Abstract excerpt

<p>By largely unknown mechanisms, dysregulated gene-specific translation directly contributes to chronic inflammation-associated diseases such as sepsis and ARDS. Here, we report that G9a, a histone methyltransferase and well-regarded transcriptional repressor, non-canonically or non-epigenetically activates translation of select antimicrobial genes to promote proliferation of cytokine producing macrophages and to...

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Literature Corpus work: 8fa4cdb5-b8c0-5558-a2e8-90abca93e3eb
DOI: 10.2139/ssrn.3962440

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