Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming.

Human molecular genetics - 15 Aug 2015

Yokota Mutsumi, Hatakeyama Hideyuki, Okabe Saki, Ono Yasuha, Goto Yu-ichi

Abstract excerpt

Mitochondrial dysfunction caused by pathogenic mutations in mitochondrial tRNA genes emerges only when mutant mitochondrial DNA (mtDNA) proportions exceed intrinsic pathogenic thresholds; however, little is known about the actual proportions of mutant mtDNA that can affect particular cellular lineage-determining processes. Here, we mainly focused on the effects of mitochondrial respiratory dysfunction caused by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Reprogramming
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Mitochondrial Diseases

Share to Mutation

Share to RNA, Transfer

Source

Identifiers

PMID: 26025377
DOI: 10.1093/hmg/ddv201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming.PMID 26025377Read ↗

Generation of a human induced pluripotent stem cell line harboring heteroplasmic m.3243A > G mutation in MT-TL1 gene.Semantic proximity Read ↗

Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics.Semantic proximity Read ↗

Generation of Somatic Mitochondrial DNA-Replaced Cells for Mitochondrial Dysfunction TreatmentSemantic proximity Read ↗

Cell reprogramming shapes the mitochondrial DNA landscape.Semantic proximity Read ↗

Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A).Semantic proximity Read ↗

Molecular pathomechanisms and cell-type-specific disease phenotypes of MELAS caused by mutant mitochondrial tRNA(Trp).Semantic proximity Read ↗

Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders.Semantic proximity Read ↗

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.Semantic proximity Read ↗

Mitochondrial respiratory dysfunction disturbs neuronal and cardiac lineage commitment of human iPSCs.Semantic proximity Read ↗

The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs.Semantic proximity Read ↗

Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects.Semantic proximity Read ↗

Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.