Article
Polygenic Risk Score Improves Risk Stratification and Prediction of Subsequent Thyroid Cancer after Childhood Cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2021
Song Nan, Liu Qi, Wilson Carmen L, Sapkota Yadav, Ehrhardt Matthew J, Gibson Todd M, Morton Lindsay M, Chanock Stephen J, Neglia Joseph P, Arnold Michael A, Michael J Robert, Gout Alexander M, Mulder Heather L, Easton John, Bhatia Smita, Armstrong Gregory T, Zhang Jinghui, Delaney Angela, Hudson Melissa M, Robison Leslie L, Yasui Yutaka, Wang Zhaoming
Abstract excerpt
BACKGROUND: Subsequent thyroid cancer (STC) is one of the most common malignancies in childhood cancer survivors. We aimed to evaluate the polygenic contributions to STC risk and potential utility in improving risk prediction. METHODS: A polygenic risk score (PRS) was calculated from 12 independent SNPs associated with thyroid cancer risk in the general population. Associations between PRS and STC risk were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.