Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study.

doi:10.1016/S1470-2045(25)00157-3

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Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study.

The Lancet. Oncology - 1 Jun 2025

Neupane Achal, Liu Qi, Taneja Siddhant, French Jennifer, Ehrhardt Matthew J, Brinkman Tara M, Webster Rachel, Yang Jun J, Im Cindy, Turcotte Lucie M, Neglia Joseph P, Gramatges M Monica, Howell Rebecca M, Bhatia Smita, Ness Kirsten K, Hudson Melissa M, Armstrong Gregory T, Robison Leslie L, Yasui Yutaka, Sapkota Yadav

Abstract excerpt

BACKGROUND: Survivors of childhood cancer are at risk of subsequent neoplasms (SNs) associated with exposure to radiotherapy and chemotherapy, as well as with genetic predisposition. We aimed to estimate the relative contributions of these risk factors to the total SN burden in survivor populations. METHODS: We analysed data from two retrospectively constructed cohorts with ongoing recruitment and prospective...

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PMID: 40449499
DOI: 10.1016/S1470-2045(25)00157-3
PMCID: PMC12204326

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