Article
Genetic variation in POT1 and risk of thyroid subsequent malignant neoplasm: A report from the Childhood Cancer Survivor Study.
PloS one - 1 Jan 2020
Richard Melissa A, Lupo Philip J, Morton Lindsay M, Yasui Yutaka A, Sapkota Yadav A, Arnold Michael A, Aubert Geraldine, Neglia Joseph P, Turcotte Lucie M, Leisenring Wendy M, Sampson Joshua N, Chanock Stephen J, Hudson Melissa M, Armstrong Gregory T, Robison Leslie L, Bhatia Smita, Gramatges Maria Monica
Abstract excerpt
BACKGROUND: Telomere length is associated with risk for thyroid subsequent malignant neoplasm in survivors of childhood cancer. Here, we investigated associations between thyroid subsequent malignant neoplasm and inherited variation in telomere maintenance genes. METHODS: We used RegulomeDB to annotate the functional impact of variants mapping to 14 telomere maintenance genes among 5,066 five-or-more year...
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