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Article

Pan-cancer polygenic risk score associates with cancer susceptibility following kidney transplantation.

JCI insight - 8 Jun 2026

Ritari Jarmo, Hyvärinen Kati, Jahnukainen Kirsi, Partanen Jukka, Helanterä Ilkka, Jahnukainen Timo

Abstract excerpt

BACKGROUNDCancer accounts for over 20% of late posttransplant mortality, yet the contribution of genetic susceptibility to posttransplant cancer risk remains unclear. This study investigates germline genetic risk factors for posttransplant cancer in the Finnish population using data from the FinnGen cohort.METHODSA pan-cancer polygenic risk score (PRS) was constructed using genetic variants identified in UK and...

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PMID: 42024473
DOI: 10.1172/jci.insight.198098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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