Article
Leveraging Therapy-Specific Polygenic Risk Scores to Predict Restrictive Lung Defects in Childhood Cancer Survivors.
Cancer research - 16 Aug 2022
Im Cindy, Yuan Yan, Austin Eric D, Stokes Dennis C, Krasin Matthew J, Davidoff Andrew M, Sapkota Yadav, Wang Zhaoming, Ness Kirsten K, Wilson Carmen L, Armstrong Gregory T, Hudson Melissa M, Robison Leslie L, Mulrooney Daniel A, Yasui Yutaka
Abstract excerpt
Therapy-related pulmonary complications are among the leading causes of morbidity among long-term survivors of childhood cancer. Restrictive ventilatory defects (RVD) are prevalent, with risks increasing after exposures to chest radiotherapy and radiomimetic chemotherapies. Using whole-genome sequencing data from 1,728 childhood cancer survivors in the St. Jude Lifetime Cohort Study, we developed and validated a...
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