Polygenic Score for Clinicopathologic Features and Survival Outcomes in Papillary Thyroid Carcinoma.

doi:10.1001/jamaoto.2024.3963

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Article

Polygenic Score for Clinicopathologic Features and Survival Outcomes in Papillary Thyroid Carcinoma.

JAMA otolaryngology-- head & neck surgery - 1 Feb 2025

Li Sophie, Zheng Guibin, Xu Li, Goswami Maitrayee, Zafereo Mark E, Sherman Steven I, Li Guojun, Sturgis Erich M, Wang Jennifer R

Abstract excerpt

Importance: Genome-wide association studies have identified germline variants associated with the development of papillary thyroid carcinoma (PTC) that can be used to construct a polygenic score (PGS). It is important to determine whether patients with higher germline genetic risk, as summarized using PGS, present with more aggressive disease and/or develop worse clinical outcomes. Objective: To assess whether...

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Topics

Humans
Female
Thyroid Cancer, Papillary
Male
Thyroid Neoplasms
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Adult

Genome-Wide Association Study

Survival Rate

Germ-Line Mutation

Multifactorial Inheritance

Aged

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 39602114
DOI: 10.1001/jamaoto.2024.3963
PMCID: PMC11826360

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