Article
Assessing thyroid cancer risk using polygenic risk scores.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2020
Liyanarachchi Sandya, Gudmundsson Julius, Ferkingstad Egil, He Huiling, Jonasson Jon G, Tragante Vinicius, Asselbergs Folkert W, Xu Li, Kiemeney Lambertus A, Netea-Maier Romana T, Mayordomo Jose I, Plantinga Theo S, Hjartarson Hannes, Hrafnkelsson Jon, Sturgis Erich M, Brock Pamela, Nabhan Fadi, Thorleifsson Gudmar, Ringel Matthew D, Stefansson Kari, de la Chapelle Albert
Abstract excerpt
Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed the combined genetic effects of these variants on PTC risk by using summarized GWAS results to build polygenic risk score (PRS) models in three PTC study groups...
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