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Article

OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1.

Diabetes - 1 Nov 2021

Mohan Ramkumar, Jo Seokwon, Lockridge Amber, Ferrington Deborah A, Murray Kevin, Eschenlauer Arthur, Bernal-Mizrachi Ernesto, Fujitani Yoshio, Alejandro Emilyn U

Abstract excerpt

O-GlcNAc transferase (OGT), a nutrient sensor sensitive to glucose flux, is highly expressed in the pancreas. However, the role of OGT in the mitochondria of β-cells is unexplored. In this study, we identified the role of OGT in mitochondrial function in β-cells. Constitutive deletion of OGT (βOGTKO) or inducible ablation in mature β-cells (iβOGTKO) causes distinct effects on mitochondrial morphology and...

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Identifiers

PMID: 34462257
DOI: 10.2337/db21-0468
PMCID: PMC8564412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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