Article

Limitations in PPAR⍺-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells

2024-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Pluripotent stem cell (SC)-derived islets offer hope as a renewable source for β cell replacement for type 1 diabetes (T1D), yet functional and metabolic immaturity may limit their long-term therapeutic potential. Here, we show that limitations in mitochondrial transcriptional programming impede the formation of SC-derived β (SC-β) cells. Utilizing transcriptomic profiling, assessments of chroma...

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Literature Corpus work: b1dc33e5-e405-5a74-a15a-c4fd33a4dee7
DOI: 10.1101/2024.07.26.605318

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