Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pdx1 ( <i>MODY4</i> ) regulates pancreatic beta cell susceptibility to ER stress

23 Oct 2009

Abstract excerpt

Type 2 diabetes mellitus (T2DM) results from pancreatic beta cell failure in the setting of insulin resistance. Heterozygous mutations in the gene encoding the beta cell transcription factor pancreatic duodenal homeobox 1 (Pdx1) are associated with both T2DM and maturity onset diabetes of the young (MODY4), and low levels of Pdx1 accompany beta cell dysfunction in experimental models of glucotoxicity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19855005
DOI: 10.1073/pnas.0904849106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pdx1 ( <i>MODY4</i> ) regulates pancreatic beta cell susceptibility to ER stressPMID 19855005Read ↗

A PDX1-ATF transcriptional complex governs β cell survival during stressSemantic proximity Read ↗

FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stressSemantic proximity Read ↗

Pancreatic Duodenal Homeobox (PDX-1) in health and disease.Semantic proximity Read ↗

Diabetes Susceptibility Genes <i>Pdx1</i> and <i>Clec16a</i> Function in a Pathway Regulating Mitophagy in β-CellsSemantic proximity Read ↗

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell FunctionSemantic proximity Read ↗

Pdx1 and other factors that regulate pancreatic β‐cell survivalSemantic proximity Read ↗

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read ↗

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during DiabetesSemantic proximity Read ↗

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feedingSemantic proximity Read ↗

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceSemantic proximity Read ↗

An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesisSemantic proximity Read ↗

Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.