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Mitophagy protects beta cells from inflammatory damage in diabetes

2020-06-09

Abstract excerpt

Inflammatory damage contributes to β-cell failure in type 1 and 2 diabetes (T1D and T2D). Mitochondria are damaged by inflammatory signaling in β-cells, resulting in impaired bioenergetics and initiation of pro-apoptotic machinery. Hence, the identification of protective responses to inflammation could lead to new therapeutic targets. Here we report that mitophagy serves as a protective response to inflammatory st...

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Identifiers and source

Literature Corpus work
48338d12-ad19-5f0a-bc1a-2d30d458582b
DOI
10.1101/2020.06.07.138917
Open publication

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Mitophagy protects beta cells from inflammatory damage in diabetesDOI 10.1101/2020.06.07.138917
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