SNP rs4971059 predisposes to breast carcinogenesis and chemoresistance via TRIM46-mediated HDAC1 degradation.

doi:10.15252/embj.2021107974

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Article

SNP rs4971059 predisposes to breast carcinogenesis and chemoresistance via TRIM46-mediated HDAC1 degradation.

The EMBO journal - 1 Oct 2021

Zhang Zihan, Liu Xiaoping, Li Lei, Yang Yang, Yang Jianguo, Wang Yue, Wu Jiajing, Wu Xiaodi, Shan Lin, Pei Fei, Liu Jianying, Wang Shu, Li Wei, Sun Luyang, Liang Jing, Shang Yongfeng

Abstract excerpt

Identification of the driving force behind malignant transformation holds the promise to combat the relapse and therapeutic resistance of cancer. We report here that the single nucleotide polymorphism (SNP) rs4971059, one of 65 new breast cancer risk loci identified in a recent genome-wide association study (GWAS), functions as an active enhancer of TRIM46 expression. Recreating the G-to-A polymorphic switch...

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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

Share to Enhancer Elements, Genetic

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Identifiers

PMID: 34459501
DOI: 10.15252/embj.2021107974
PMCID: PMC8488578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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