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Article

PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR.

Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2024

Guan Anqi, Dai Ziyu, Jiang Chen, Sun Jingyi, Yang Baishuang, Xie Bin, Chen Qiong

Abstract excerpt

Cancer stem cells (CSCs) are responsible for tumor chemoresistance, and the aryl hydrocarbon receptor (AHR) is indispensable for maintaining CSC characteristics. Here, we aimed to investigate how the interaction between progesterone receptor membrane component 1 (PGRMC1) and AHR contributes to the maintenance of CSC phenotypes in non-small cell lung cancer (NSCLC). Clinical data and tissue microarray analyses...

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Identifiers

PMID: 39059592
DOI: 10.1016/j.bbadis.2024.167440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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