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Article

NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants.

eLife - 27 Aug 2021

Guerrero Gabriel A, Derisbourg Maxime J, Mayr Felix Amc, Wester Laura E, Giorda Marco, Dinort J Eike, Hartman Matías D, Schilling Klara, Alonso-De Gennaro María José, Lu Ryan J, Benayoun Bérénice A, Denzel Martin S

Abstract excerpt

Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mutants in the intraflagellar transport protein gene osm-3 were significantly protected from tunicamycin-induced ER stress. While osm-3 lifespan extension is dependent...

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PMID: 34448454
DOI: 10.7554/eLife.53174
PMCID: PMC8460253

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Source receipt: pubmed, retrieved 7 Sept 2026.

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