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Article

Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses.

PloS one - 1 Jan 2014

Ward Jordan D, Mullaney Brendan, Schiller Benjamin J, He Le D, Petnic Sarah E, Couillault Carole, Pujol Nathalie, Bernal Teresita U, Van Gilst Marc R, Ashrafi Kaveh, Ewbank Jonathan J, Yamamoto Keith R

Abstract excerpt

Metazoan transcription factors control distinct networks of genes in specific tissues, yet understanding how these networks are integrated into physiology, development, and homeostasis remains challenging. Inactivation of the nuclear hormone receptor nhr-25 ameliorates developmental and metabolic phenotypes associated with loss of function of an acyl-CoA synthetase gene, acs-3. ACS-3 activity prevents aberrantly...

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Identifiers

PMID: 24651852
DOI: 10.1371/journal.pone.0092552
PMCID: PMC3961378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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