Article
A shift to organismal stress resistance in programmed cell death mutants.
PLoS genetics - 1 Jan 2013
Judy Meredith E, Nakamura Ayumi, Huang Anne, Grant Harli, McCurdy Helen, Weiberth Kurt F, Gao Fuying, Coppola Giovanni, Kenyon Cynthia, Kao Aimee W
Abstract excerpt
Animals have many ways of protecting themselves against stress; for example, they can induce animal-wide, stress-protective pathways and they can kill damaged cells via apoptosis. We have discovered an unexpected regulatory relationship between these two types of stress responses. We find that C. elegans mutations blocking the normal course of programmed cell death and clearance confer animal-wide resistance to a...
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