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Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in <i>Drosophila</i>

2021-05-10

Abstract excerpt

Mutations in ribosome protein ( Rp ) genes and ribosome biogenesis factors result in debilitating diseases known as ribosomopathies. Recent studies in Drosophila have shown that cells heterozygous mutant for Rp genes ( Rp/+ ) exhibit proteotoxic stress and aggregates, which drive stress pathway activation and apoptosis. Understanding how Rp/+ cells fend off proteotoxic stress could suggest mechanisms to ameli...

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Literature Corpus work
0342ef23-e4f5-5fdf-9399-fd89e95127b7
DOI
10.1101/2021.05.10.443504
Open publication

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Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in <i>Drosophila</i>DOI 10.1101/2021.05.10.443504
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