Article

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues

2023-04-25

Abstract excerpt

The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence organismal stress resilience in C. elegans . We previously uncovered a pathway that links the integrity of developing embryos to somatic health in reproductive adults. Here, we show that the nuclear recepto...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4ea415d3-bd31-5be1-b5de-680e59eb4eb0
DOI: 10.1101/2023.04.25.537803

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cuesDOI 10.1101/2023.04.25.537803Read

Nuclear hormone receptor NHR-49 is an essential regulator of stress resilience and healthy aging in Caenorhabditis elegansSemantic proximity Read

Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegansSemantic proximity Read

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor PartnershipsSemantic proximity Read

Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans.Semantic proximity Read

Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegansSemantic proximity Read

Nutrient sensing pathways regulating adult reproductive diapause in C. elegansSemantic proximity Read

Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans.Semantic proximity Read

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.Semantic proximity Read

Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegansSemantic proximity Read

Nuclear hormone receptor NHR-49 shapes immuno-metabolic response of <i>Caenorhabditis elegans to Enterococcus faecalis</i> infectionSemantic proximity Read

Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans.Semantic proximity Read

DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.Semantic proximity Read