Article
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments.
Genetics - 1 May 2004
Solomon Aharon, Bandhakavi Sricharan, Jabbar Sean, Shah Rena, Beitel Greg J, Morimoto Richard I
Abstract excerpt
The molecular mechanisms that enable multicellular organisms to sense and modulate their responses to hyperosmotic environments are poorly understood. Here, we employ Caenorhabditis elegans to characterize the response of a multicellular organism to osmotic stress and establish a genetic screen to isolate mutants that are osmotic stress resistant (OSR). In this study, we describe the cloning of a novel gene,...
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