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Article

Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion

20 Mar 2023

Abstract excerpt

Highly coordinated changes in gene expression underlie T cell activation and exhaustion. However, the mechanisms by which such programs are regulated and how these may be targeted for therapeutic benefit remain poorly understood. Here, we comprehensively profile the genomic occupancy of mSWI/SNF chromatin remodeling complexes throughout acute and chronic T cell stimulation, finding that stepwise changes in...

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PMID: 36944333
DOI: 10.1016/j.molcel.2023.02.026

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