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Article

A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells

1 Aug 2021

Abstract excerpt

Paraspeckles are membraneless organelles formed through liquid-liquid phase separation and consist of multiple proteins and RNAs, including NONO, SFPQ, and NEAT1. The role of paraspeckles and the component NONO in hematopoiesis remains unknown. In this study, we show histone modifier ASXL1 is involved in paraspeckle formation. ASXL1 forms phase-separated droplets, upregulates NEAT1 expression, and increases...

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PMID: 34433054
DOI: 10.1016/j.celrep.2021.109576

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