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Article

PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain.

Nature communications - 24 Aug 2021

Wen Maorong, Cao Yunlei, Wu Bin, Xiao Taoran, Cao Ruiyu, Wang Qian, Liu Xiwei, Xue Hongjuan, Yu Yang, Lin Jialing, Xu Chenqi, Xu Jie, OuYang Bo

Abstract excerpt

The cytoplasmic domain of PD-L1 (PD-L1-CD) regulates PD-L1 degradation and stability through various mechanism, making it an attractive target for blocking PD-L1-related cancer signaling. Here, by using NMR and biochemical techniques we find that the membrane association of PD-L1-CD is mediated by electrostatic interactions between acidic phospholipids and basic residues in the N-terminal region. The absence of...

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Identifiers

PMID: 34429434
DOI: 10.1038/s41467-021-25416-7
PMCID: PMC8384847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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