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Article

Mechanistic Insights into the Inhibition of a Common CTLA-4 Gene Mutation in the Cytoplasmic Domain.

Molecules (Basel, Switzerland) - 16 Mar 2024

Xu Jikang, Zhang Yu, Shen Lijuan, Du Lingyu, Xue Hongjuan, Wu Bin, OuYang Bo

Abstract excerpt

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a pivotal immune checkpoint receptor, playing a crucial role in modulating T-cell activation. In this study, we delved into the underlying mechanism by which a common mutation, G199R, in the cytoplasmic domain of CTLA-4 impacts its inhibitory function. Utilizing nuclear magnetic resonance (NMR) spectroscopy and biochemical techniques, we mapped the conformational...

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Identifiers

PMID: 38542966
DOI: 10.3390/molecules29061330
PMCID: PMC10974916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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