Article

Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Finely Alleviate Diabetes Mellitus via a Ca <sup>2+</sup> - CaMKKβ-AMPK pathway

2026-06-16

Abstract excerpt

Type 2 Diabetes mellitus (T2DM) is a metabolic syndrome characterized by hyperglycemia and various complications. Current drugs are limited by side effects and resistance, necessitating novel targets and therapies. Previous studies have shown that MK-83, a synthetic agonist of transient receptor potential mucolipin 1 (TRPML1/ MCOLN1), a lysosomal Ca 2+ channel, activates adenosine 5′-monophosphate-activated prote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb4d19d6-e70f-5de0-a414-5b40ebc24fc7
DOI: 10.64898/2026.06.16.732532

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Finely Alleviate Diabetes Mellitus via a Ca <sup>2+</sup> - CaMKKβ-AMPK pathwayDOI 10.64898/2026.06.16.732532Read

TRPML1 : role in autophagy and potential target to treat lysosomal storage disordersSemantic proximity Read

Ion Transporters, Channelopathies, and Glucose DisordersSemantic proximity Read

Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1.Semantic proximity Read

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.Semantic proximity Read

TRPML1: an ion channel in the lysosome.Semantic proximity Read

TRPML1 gating modulation by allosteric mutations and lipids.Semantic proximity Read

TRPML3.Semantic proximity Read

Molecular mechanism of action of metformin: old or new insights?Semantic proximity Read

TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytesSemantic proximity Read

The anticancer effect of Metformin targets VDAC1 via ER-mitochondria interaction-mediated autophagy in HCCSemantic proximity Read

Regulation of TRPML1 function.Semantic proximity Read

Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants.Semantic proximity Read